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Development of novel multivalent vaccines (A651)

 
One aim is to generate a multivalent vaccine against pest des petits ruminants virus (PPRV), using a segmented version of the PPRV genome as a vehicle to express heterologous immunogens of bluetongue virus (BTV) and Rift valley fever virus (RVFV) that, when incorporated into the PPR vaccine, may afford protection against a number of different diseases (PPR, BT and RVF). The other aim is to develop and validate DIVA tests for the detection of animals that have been infected with PPRV/BTV/RVFV despite prior vaccination. The viral diseases targeted in this proposal are in line with the BBSRC's Combating Diseases of the Developing World Strategy, as well as DFID's long term commitment to improving the sustainability of agriculture in developing countries.

IAH Co-Investigator: Professor Satya Parida

Principal Investigator: Dr A C Banyard, Rabies Wildlife and Zoonoses group, VLA, Weybridge, New Haw, Surrey

Dr. T. Fooks, Rabies Wildlife and Zoonoses group, VLA, Weybridge, New Haw, Surrey
Professor A Easton, Dept of Biological Sciences, University of Warwick

Overseas Collaborators:
Dr V A Srinivasan, Indian Immunologicals, Hyderabad, India
Dr J. Paweska, NICD, South Africa

Country involved: India and South Africa
Duration: 48 months
     

 
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